Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF1_AC401	4.75e-08	9.07e-01	1.04e-02	3.20e-01
AF1_AC401 Exclusive	Viral	3.55e-01	5.72e-01	4.23e-01	2.90e-09
Viral Exclusive	AF1_AC401 Exclusive	2.35e-08	9.72e-01	2.05e-02	5.53e-01
AF1_AC401 Exclusive	Viral Exclusive	4.83e-01	5.74e-01	5.75e-01	1.72e-09
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF1_AC401 Exclusive	Overlap	7.93e-01	7.93e-01	4.53e-01	8.47e-01
Overlap	Exclusives	1.95e-15	1.51e-12	1.78e-13	2.00e-19



Evaluating how well Viral genes are linked to AF1_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF1_AC401	0.53	0.49	0.23	0.67	1.15
AF1_AC401 Exclusive	Viral	0.67	-0.14	0.74	0.39	5.68
Viral Exclusive	AF1_AC401 Exclusive	0.53	0.47	0.03	0.18	1.06
AF1_AC401 Exclusive	Viral Exclusive	0.67	-0.00	0.56	0.32	5.94
Viral Exclusive	Overlap	1.00	2.44	1.78	3.02	1.61
AF1_AC401 Exclusive	Overlap	0.53	0.17	-0.02	0.55	0.03
Overlap	Exclusives	0.67	2.13	7.14	2.17	9.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF1_AC401	0.01	0.62	0.09	0.17	0.62
AF1_AC401 Exclusive	Viral	0.01	-0.72	-0.58	-0.26	1.73
Viral Exclusive	AF1_AC401 Exclusive	0.01	0.44	-0.26	-0.17	0.30
AF1_AC401 Exclusive	Viral Exclusive	0.01	-0.60	-0.57	-0.29	2.86
Viral Exclusive	Overlap	0.01	92.76	19.28	131.11	34.11
AF1_AC401 Exclusive	Overlap	0.00	-0.24	-0.31	0.05	-0.18
Overlap	Exclusives	0.05	7.74	33.20	6.36	27.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	123	110	HLA-Cw;HLA;SRY;Mig;IFNL4;HLA-DRB3;MBL3P;HLA-DRB4;UNC93B;SNORA31;IL12;FCER;TNFα
AF1_AC401 Exclusive	161	160	CCDC7
Overlap	1	1