Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	AF1_AC401	3.72e-05	6.38e-01	2.36e-02	1.10e-01
AF1_AC401 Exclusive	Covid	8.29e-01	4.15e-01	4.38e-01	4.23e-08
Covid Exclusive	AF1_AC401 Exclusive	2.90e-05	8.20e-01	4.56e-02	1.47e-01
AF1_AC401 Exclusive	Covid Exclusive	8.39e-01	3.18e-01	5.08e-01	8.76e-09
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.12e-01
AF1_AC401 Exclusive	Overlap	7.73e-01	8.29e-01	6.52e-01	6.31e-01
Overlap	Exclusives	1.73e-08	3.15e-07	5.45e-07	9.19e-13



Evaluating how well Covid genes are linked to AF1_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF1_AC401	0.54	1.25	0.62	0.90	1.56
AF1_AC401 Exclusive	Covid	0.69	0.00	1.03	0.47	6.08
Covid Exclusive	AF1_AC401 Exclusive	0.53	1.02	0.41	0.58	1.61
AF1_AC401 Exclusive	Covid Exclusive	0.69	0.04	1.00	0.29	5.99
Covid Exclusive	Overlap	0.99	1.81	2.00	2.08	1.71
AF1_AC401 Exclusive	Overlap	0.53	0.26	-0.05	0.41	-0.19
Overlap	Exclusives	0.64	1.41	5.02	1.94	8.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF1_AC401	0.01	1.12	0.16	0.39	0.57
AF1_AC401 Exclusive	Covid	0.01	-0.59	-0.08	-0.25	4.23
Covid Exclusive	AF1_AC401 Exclusive	0.01	0.66	0.00	0.06	0.99
AF1_AC401 Exclusive	Covid Exclusive	0.01	-0.58	-0.02	-0.34	3.75
Covid Exclusive	Overlap	0.00	50.20	16.95	14.92	3.59
AF1_AC401 Exclusive	Overlap	0.00	-0.20	-0.30	-0.11	-0.25
Overlap	Exclusives	0.04	4.29	19.77	5.19	25.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	UNC93B;MBL3P;HLA-DRB4;SRY
AF1_AC401 Exclusive	161	160	CCDC7
Overlap	1	1