Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	AF1_AC401	3.87e-09	1.65e-01	3.10e-01	7.36e-01
AF1_AC401 Exclusive	Casanova	1.23e-02	1.11e-01	2.78e-01	1.12e-01
Casanova Exclusive	AF1_AC401 Exclusive	5.73e-10	1.77e-01	3.97e-01	6.74e-01
AF1_AC401 Exclusive	Casanova Exclusive	2.21e-02	1.11e-01	2.33e-01	1.03e-01
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF1_AC401 Exclusive	Overlap	5.30e-01	7.73e-01	5.90e-01	7.73e-01
Overlap	Exclusives	5.81e-02	7.94e-01	2.53e-01	2.05e-01



Evaluating how well Casanova genes are linked to AF1_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	AF1_AC401	0.49	-1.19	-2.47	-1.40	-0.62
AF1_AC401 Exclusive	Casanova	0.63	-1.46	-1.36	-0.42	1.32
Casanova Exclusive	AF1_AC401 Exclusive	0.48	-1.60	-2.17	-1.16	-0.63
AF1_AC401 Exclusive	Casanova Exclusive	0.64	-1.59	-1.43	-0.55	1.71
Casanova Exclusive	Overlap	1.00	2.84	2.63	1.92	1.57
AF1_AC401 Exclusive	Overlap	0.53	-0.27	0.02	0.41	0.04
Overlap	Exclusives	0.54	0.61	0.41	0.68	1.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	AF1_AC401	0.01	-0.66	-1.72	-0.84	-0.65
AF1_AC401 Exclusive	Casanova	0.00	-0.92	-1.33	-0.57	-0.17
Casanova Exclusive	AF1_AC401 Exclusive	0.01	-0.95	-1.88	-0.96	-0.91
AF1_AC401 Exclusive	Casanova Exclusive	0.00	-0.60	-1.47	-0.67	-0.05
Casanova Exclusive	Overlap	0.01	106.55	77.02	39.84	9.18
AF1_AC401 Exclusive	Overlap	0.00	-0.43	-0.24	-0.13	-0.22
Overlap	Exclusives	0.01	1.53	3.54	2.07	3.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
AF1_AC401 Exclusive	161	160	CCDC7
Overlap	1	1