Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF01_AC401	4.80e-07	8.97e-02	2.36e-05	7.64e-03
AF01_AC401 Exclusive	Viral	1.03e-02	5.36e-02	2.30e-03	4.58e-10
Viral Exclusive	AF01_AC401 Exclusive	1.78e-07	1.05e-01	5.13e-05	1.20e-02
AF01_AC401 Exclusive	Viral Exclusive	1.74e-02	4.38e-02	2.08e-03	2.48e-11
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
AF01_AC401 Exclusive	Overlap	5.50e-01	5.10e-01	6.11e-01	8.29e-01
Overlap	Exclusives	1.40e-15	4.00e-15	1.91e-15	7.68e-24



Evaluating how well Viral genes are linked to AF01_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF01_AC401	0.56	1.81	1.45	1.61	2.77
AF01_AC401 Exclusive	Viral	0.71	1.21	2.99	1.21	8.30
Viral Exclusive	AF01_AC401 Exclusive	0.55	1.67	1.35	1.33	2.38
AF01_AC401 Exclusive	Viral Exclusive	0.72	1.04	2.79	1.03	7.95
Viral Exclusive	Overlap	1.00	2.39	1.89	2.63	1.67
AF01_AC401 Exclusive	Overlap	0.53	0.52	-0.33	0.38	0.11
Overlap	Exclusives	0.69	1.91	9.30	2.49	11.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF01_AC401	0.01	2.55	2.54	1.55	2.37
AF01_AC401 Exclusive	Viral	0.01	0.80	4.43	0.68	11.16
Viral Exclusive	AF01_AC401 Exclusive	0.01	2.11	2.31	0.94	2.18
AF01_AC401 Exclusive	Viral Exclusive	0.01	0.56	4.09	0.80	6.33
Viral Exclusive	Overlap	0.01	110.89	16.27	125.81	6.11
AF01_AC401 Exclusive	Overlap	0.00	0.07	-0.23	-0.12	-0.16
Overlap	Exclusives	0.06	4.56	31.67	5.71	45.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	123	110	SNORA31;HLA;FCER;TNFα;SRY;IL12;MBL3P;Mig;HLA-DRB4;HLA-DRB3;UNC93B;IFNL4;HLA-Cw
AF01_AC401 Exclusive	191	189	CCDC7;C1GALT1C1L
Overlap	1	1