Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	AF01_AC401	1.25e-07	1.18e-01	1.98e-04	4.71e-02
AF01_AC401 Exclusive	Covid	1.22e-01	3.02e-01	3.65e-02	3.51e-08
Covid Exclusive	AF01_AC401 Exclusive	3.88e-07	1.60e-01	1.90e-04	4.65e-02
AF01_AC401 Exclusive	Covid Exclusive	1.31e-01	3.02e-01	3.75e-02	2.70e-08
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
AF01_AC401 Exclusive	Overlap	6.73e-01	5.90e-01	4.72e-01	8.47e-01
Overlap	Exclusives	9.13e-11	4.62e-10	1.24e-09	6.13e-17



Evaluating how well Covid genes are linked to AF01_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF01_AC401	0.55	1.55	1.03	0.85	2.28
AF01_AC401 Exclusive	Covid	0.70	0.71	1.89	0.77	5.90
Covid Exclusive	AF01_AC401 Exclusive	0.55	1.30	1.03	1.16	2.47
AF01_AC401 Exclusive	Covid Exclusive	0.71	0.72	1.56	0.70	6.10
Covid Exclusive	Overlap	0.99	1.84	1.71	2.53	1.63
AF01_AC401 Exclusive	Overlap	0.53	0.36	-0.35	0.36	0.05
Overlap	Exclusives	0.67	1.77	8.21	2.35	9.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF01_AC401	0.01	1.94	2.36	0.80	1.91
AF01_AC401 Exclusive	Covid	0.01	0.13	2.75	0.45	3.33
Covid Exclusive	AF01_AC401 Exclusive	0.01	1.15	1.87	1.30	1.59
AF01_AC401 Exclusive	Covid Exclusive	0.01	0.19	2.65	0.33	6.60
Covid Exclusive	Overlap	0.00	22.94	11.05	66.24	0.31
AF01_AC401 Exclusive	Overlap	0.00	-0.20	-0.30	-0.14	-0.14
Overlap	Exclusives	0.04	3.66	17.66	3.95	24.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	MBL3P;HLA-DRB4;UNC93B;SRY
AF01_AC401 Exclusive	191	189	CCDC7;C1GALT1C1L
Overlap	1	1