Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova Exclusive	AF01_AC401	3.54e-06	8.17e-01	1.38e-02	1.73e-01
AF01_AC401 Exclusive	Casanova	9.97e-01	5.24e-01	4.36e-01	6.03e-03
Casanova Exclusive	AF01_AC401 Exclusive	1.62e-06	8.72e-01	3.69e-02	2.07e-01
AF01_AC401 Exclusive	Casanova Exclusive	9.99e-01	4.88e-01	4.36e-01	6.94e-03
Casanova Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF01_AC401 Exclusive	Overlap	6.93e-01	6.52e-01	3.51e-01	5.10e-01
Overlap	Exclusives	1.58e-01	2.68e-02	5.10e-01	7.01e-05



Evaluating how well Casanova genes are linked to AF01_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	AF01_AC401	0.54	1.43	0.16	0.20	2.00
AF01_AC401 Exclusive	Casanova	0.74	0.17	1.33	0.62	3.40
Casanova Exclusive	AF01_AC401 Exclusive	0.54	1.23	-0.10	0.04	2.20
AF01_AC401 Exclusive	Casanova Exclusive	0.76	0.08	1.29	0.53	2.97
Casanova Exclusive	Overlap	1.00	2.75	2.83	1.95	1.69
AF01_AC401 Exclusive	Overlap	0.53	-0.00	-0.24	0.61	0.33
Overlap	Exclusives	0.59	1.53	3.83	1.80	4.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova Exclusive	AF01_AC401	0.01	1.72	0.86	0.49	1.89
AF01_AC401 Exclusive	Casanova	0.00	-0.32	0.77	-0.11	0.35
Casanova Exclusive	AF01_AC401 Exclusive	0.01	1.07	0.42	0.16	1.41
AF01_AC401 Exclusive	Casanova Exclusive	0.00	-0.37	0.86	-0.12	2.55
Casanova Exclusive	Overlap	0.01	170.31	76.29	8.82	17.84
AF01_AC401 Exclusive	Overlap	0.00	-0.24	-0.28	-0.03	-0.24
Overlap	Exclusives	0.02	1.90	4.13	2.94	6.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova Exclusive	12	11	UNC93B
AF01_AC401 Exclusive	191	189	C1GALT1C1L;CCDC7
Overlap	1	1