Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF01_AC40	4.11e-05	9.85e-01	2.74e-01	8.37e-02
AF01_AC40	Casanova	5.00e-01	9.24e-01	9.97e-01	7.30e-02



Evaluating how well Casanova genes are linked to AF01_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC40	0.54	1.69	0.05	0.38	1.90
AF01_AC40	Casanova	0.67	-0.55	-0.14	-0.12	2.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF01_AC40	0.01	1.03	0.10	0.23	1.25
AF01_AC40	Casanova	0.00	-0.58	-0.25	-0.43	0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF01_AC40	179	177	CCDC7;C1GALT1C1L