Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF01_AC40	1.01e-07	4.40e-01	1.68e-03	1.58e-01
AF01_AC40	Covid	7.99e-02	4.71e-01	9.91e-03	1.40e-07



Evaluating how well Covid genes are linked to AF01_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF01_AC40	0.55	1.29	0.84	1.09	2.38
AF01_AC40	Covid	0.70	0.73	1.06	0.72	5.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF01_AC40	0.01	0.94	1.65	0.44	1.56
AF01_AC40	Covid	0.01	0.65	2.95	0.96	9.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;SRY;UNC93B;MBL3P
AF01_AC40	179	177	CCDC7;C1GALT1C1L