Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF01_AC40	1.14e-06	3.00e-01	1.70e-04	1.97e-02
AF01_AC40	Viral	2.02e-03	4.66e-02	3.97e-04	7.14e-10



Evaluating how well Viral genes are linked to AF01_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC40	0.55	1.60	1.04	1.14	2.20
AF01_AC40	Viral	0.70	1.28	2.29	1.02	7.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF01_AC40	0.01	1.17	2.15	0.91	1.70
AF01_AC40	Viral	0.01	1.33	4.42	1.15	11.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	124	111	SNORA31;UNC93B;MBL3P;HLA-Cw;SRY;HLA;HLA-DRB3;IFNL4;FCER;TNFα;Mig;HLA-DRB4;IL12
AF01_AC40	179	177	CCDC7;C1GALT1C1L