Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF001_AC401	2.36e-15	9.55e-01	1.84e-02	2.57e-01
AF001_AC401 Exclusive	Viral	1.53e-01	2.19e-01	2.21e-01	2.59e-05
Viral Exclusive	AF001_AC401 Exclusive	4.48e-16	7.84e-01	1.81e-02	2.15e-01
AF001_AC401 Exclusive	Viral Exclusive	8.97e-02	2.53e-01	1.89e-01	1.42e-04
Viral Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
AF001_AC401 Exclusive	Overlap	5.93e-01	8.92e-01	2.58e-01	1.38e-01
Overlap	Exclusives	6.15e-12	3.94e-12	6.36e-23	1.19e-18



Evaluating how well Viral genes are linked to AF001_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF001_AC401	0.53	-1.33	-0.45	-0.11	1.84
AF001_AC401 Exclusive	Viral	0.63	-0.52	-2.45	-0.38	4.47
Viral Exclusive	AF001_AC401 Exclusive	0.53	-1.56	-0.90	-0.23	1.35
AF001_AC401 Exclusive	Viral Exclusive	0.63	-0.59	-2.32	-0.47	4.32
Viral Exclusive	Overlap	1.00	2.96	2.40	3.08	2.59
AF001_AC401 Exclusive	Overlap	0.82	1.50	0.80	1.53	1.62
Overlap	Exclusives	0.67	2.50	7.68	2.34	10.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF001_AC401	0.01	-1.23	-0.09	0.09	1.13
AF001_AC401 Exclusive	Viral	0.01	-0.76	-2.23	-0.51	2.07
Viral Exclusive	AF001_AC401 Exclusive	0.01	-1.87	-1.05	-0.42	0.31
AF001_AC401 Exclusive	Viral Exclusive	0.01	-0.75	-2.52	-0.54	2.83
Viral Exclusive	Overlap	0.02	25.75	65.01	112.59	5.35
AF001_AC401 Exclusive	Overlap	0.00	-0.12	-0.34	0.14	0.37
Overlap	Exclusives	0.06	12.58	38.63	8.46	52.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	122	109	HLA-Cw;Mig;FCER;SNORA31;IL12;MBL3P;HLA;TNFα;UNC93B;HLA-DRB4;IFNL4;SRY;HLA-DRB3
AF001_AC401 Exclusive	196	193	CCDC7;PPIAL4E;LOC101928841
Overlap	2	2