Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	AF001_AC401	3.63e-13	9.06e-01	8.02e-03	3.51e-01
AF001_AC401 Exclusive	Covid	3.07e-01	3.85e-01	1.83e-01	1.65e-05
Covid Exclusive	AF001_AC401 Exclusive	5.46e-14	7.96e-01	2.59e-03	4.10e-01
AF001_AC401 Exclusive	Covid Exclusive	1.76e-01	3.69e-01	8.36e-02	2.34e-05
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF001_AC401 Exclusive	Overlap	1.12e-01	1.75e-01	1.12e-01	2.78e-01
Overlap	Exclusives	8.47e-10	1.23e-07	6.56e-09	1.92e-13



Evaluating how well Covid genes are linked to AF001_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF001_AC401	0.53	-1.27	-1.08	-0.41	1.43
AF001_AC401 Exclusive	Covid	0.66	-0.12	-1.21	-0.18	5.27
Covid Exclusive	AF001_AC401 Exclusive	0.52	-1.52	-1.26	-0.83	1.30
AF001_AC401 Exclusive	Covid Exclusive	0.66	-0.42	-1.09	-0.16	5.28
Covid Exclusive	Overlap	0.99	2.12	1.85	2.14	1.90
AF001_AC401 Exclusive	Overlap	0.85	2.28	1.22	2.27	1.18
Overlap	Exclusives	0.64	1.47	4.86	1.84	8.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF001_AC401	0.01	-1.09	-0.64	-0.12	0.47
AF001_AC401 Exclusive	Covid	0.01	-0.64	-1.53	-0.46	3.64
Covid Exclusive	AF001_AC401 Exclusive	0.01	-1.58	-0.95	-0.66	0.67
AF001_AC401 Exclusive	Covid Exclusive	0.01	-0.86	-1.29	-0.48	1.52
Covid Exclusive	Overlap	0.00	33.94	18.19	61.81	20.66
AF001_AC401 Exclusive	Overlap	0.00	2.23	-0.11	2.68	-0.09
Overlap	Exclusives	0.04	4.71	25.76	5.95	27.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	HLA-DRB4;SRY;MBL3P;UNC93B
AF001_AC401 Exclusive	197	194	CCDC7;PPIAL4E;LOC101928841
Overlap	1	1