Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF001_AC40	1.43e-13	5.99e-01	1.31e-02	1.43e-01
AF001_AC40 Exclusive	Viral	4.15e-01	1.36e-01	7.07e-03	6.85e-08
Viral Exclusive	AF001_AC40 Exclusive	1.33e-13	4.97e-01	1.66e-02	1.72e-01
AF001_AC40 Exclusive	Viral Exclusive	4.71e-01	2.02e-01	1.27e-02	1.48e-07
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF001_AC40 Exclusive	Overlap	5.70e-01	4.17e-01	2.06e-01	1.66e-01
Overlap	Exclusives	3.14e-15	5.96e-13	2.71e-43	1.04e-21



Evaluating how well Viral genes are linked to AF001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF001_AC40	0.53	-1.92	-1.09	-0.47	1.76
AF001_AC40 Exclusive	Viral	0.67	0.19	-0.49	0.31	5.85
Viral Exclusive	AF001_AC40 Exclusive	0.53	-1.83	-1.32	-0.47	1.38
AF001_AC40 Exclusive	Viral Exclusive	0.66	0.16	-0.37	0.25	6.62
Viral Exclusive	Overlap	1.00	1.46	2.97	1.68	1.74
AF001_AC40 Exclusive	Overlap	0.91	0.09	0.15	0.52	1.42
Overlap	Exclusives	0.68	3.01	7.29	2.64	10.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF001_AC40	0.01	-1.82	-0.41	-0.23	1.53
AF001_AC40 Exclusive	Viral	0.01	-0.70	-1.66	-0.28	4.09
Viral Exclusive	AF001_AC40 Exclusive	0.01	-1.94	-0.95	-0.42	0.80
AF001_AC40 Exclusive	Viral Exclusive	0.01	-0.58	-1.43	-0.38	5.49
Viral Exclusive	Overlap	0.01	16.22	204.34	48.10	10.08
AF001_AC40 Exclusive	Overlap	0.00	-0.34	-0.52	-0.14	0.20
Overlap	Exclusives	0.05	19.29	38.16	9.19	47.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	123	110	TNFα;FCER;UNC93B;HLA-DRB3;MBL3P;SNORA31;Mig;IL12;SRY;HLA;HLA-Cw;IFNL4;HLA-DRB4
AF001_AC40 Exclusive	184	180	PPIAL4E;LOC101928841;CCDC7;PRAG1
Overlap	1	1