Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF001_AC40	4.00e-12	4.16e-01	2.30e-03	5.54e-01
AF001_AC40	Covid	6.70e-01	4.64e-01	8.28e-04	9.96e-09



Evaluating how well Covid genes are linked to AF001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC40	0.53	-1.49	-1.81	-0.60	1.34
AF001_AC40	Covid	0.70	0.47	1.12	0.78	7.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF001_AC40	0.01	-1.13	-0.78	-0.20	1.22
AF001_AC40	Covid	0.01	-0.61	-0.60	-0.04	5.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;SRY;UNC93B;MBL3P
AF001_AC40	185	181	PRAG1;CCDC7;PPIAL4E;LOC101928841