Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF001_AC40	9.65e-12	2.63e-01	1.23e-01	1.04e-01
AF001_AC40	Casanova	6.78e-01	7.53e-02	1.86e-02	1.05e-03



Evaluating how well Casanova genes are linked to AF001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC40	0.53	-0.64	-1.68	-1.02	1.18
AF001_AC40	Casanova	0.80	0.47	2.61	0.95	3.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF001_AC40	0.01	0.04	-0.92	-0.29	0.58
AF001_AC40	Casanova	0.00	-0.35	0.83	-0.02	1.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF001_AC40	185	181	LOC101928841;CCDC7;PPIAL4E;PRAG1