Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	AF0001_AC401	7.90e-11	9.61e-01	2.28e-03	1.41e-03
AF0001_AC401 Exclusive	Viral	5.73e-01	6.83e-01	3.85e-04	5.20e-10
Viral Exclusive	AF0001_AC401 Exclusive	7.14e-11	9.84e-01	3.99e-03	8.88e-04
AF0001_AC401 Exclusive	Viral Exclusive	4.02e-01	6.58e-01	1.98e-04	2.32e-09
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
AF0001_AC401 Exclusive	Overlap	1.41e-01	2.65e-01	1.33e-01	3.83e-01
Overlap	Exclusives	2.18e-16	3.05e-13	1.10e-14	1.01e-26



Evaluating how well Viral genes are linked to AF0001_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF0001_AC401	0.59	-0.77	0.21	0.56	3.86
AF0001_AC401 Exclusive	Viral	0.69	0.17	0.34	0.87	7.22
Viral Exclusive	AF0001_AC401 Exclusive	0.58	-0.99	0.19	0.59	3.34
AF0001_AC401 Exclusive	Viral Exclusive	0.69	0.02	0.61	0.97	6.38
Viral Exclusive	Overlap	1.00	2.66	1.89	2.50	1.83
AF0001_AC401 Exclusive	Overlap	0.74	1.56	0.87	1.56	0.77
Overlap	Exclusives	0.71	2.00	7.13	2.00	12.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	AF0001_AC401	0.01	-1.10	0.04	0.61	3.17
AF0001_AC401 Exclusive	Viral	0.01	-0.63	-0.77	0.29	4.40
Viral Exclusive	AF0001_AC401 Exclusive	0.01	-1.62	-0.18	0.46	2.62
AF0001_AC401 Exclusive	Viral Exclusive	0.01	-0.68	-0.62	0.42	7.52
Viral Exclusive	Overlap	0.01	97.43	53.01	136.63	30.08
AF0001_AC401 Exclusive	Overlap	0.00	1.02	-0.16	0.64	-0.19
Overlap	Exclusives	0.06	6.09	35.67	5.81	58.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	123	110	HLA-DRB4;Mig;SNORA31;FCER;UNC93B;HLA;SRY;TNFα;IL12;HLA-Cw;HLA-DRB3;IFNL4;MBL3P
AF0001_AC401 Exclusive	168	168	
Overlap	1	1