Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	AF0001_AC401	2.96e-10	7.86e-01	3.01e-03	9.13e-04
AF0001_AC401 Exclusive	Covid	2.63e-01	2.42e-01	4.10e-03	6.04e-08
Covid Exclusive	AF0001_AC401 Exclusive	1.80e-09	8.25e-01	4.62e-03	6.29e-04
AF0001_AC401 Exclusive	Covid Exclusive	2.15e-01	2.86e-01	1.04e-02	2.09e-07
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
AF0001_AC401 Exclusive	Overlap	1.57e-01	2.78e-01	1.25e-01	4.72e-01
Overlap	Exclusives	6.13e-11	1.80e-08	5.37e-11	2.46e-19



Evaluating how well Covid genes are linked to AF0001_AC401 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF0001_AC401	0.58	-0.74	-0.03	0.67	3.77
AF0001_AC401 Exclusive	Covid	0.69	-0.08	0.09	0.54	6.69
Covid Exclusive	AF0001_AC401 Exclusive	0.58	-0.52	-0.11	0.62	3.98
AF0001_AC401 Exclusive	Covid Exclusive	0.69	-0.16	0.07	0.38	5.98
Covid Exclusive	Overlap	0.99	2.07	2.00	2.38	1.65
AF0001_AC401 Exclusive	Overlap	0.74	1.68	0.93	1.54	0.71
Overlap	Exclusives	0.69	1.92	5.34	2.45	9.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	AF0001_AC401	0.01	-1.01	-0.40	0.41	2.70
AF0001_AC401 Exclusive	Covid	0.01	-0.89	-1.15	-0.00	6.74
Covid Exclusive	AF0001_AC401 Exclusive	0.01	-1.16	-0.67	0.42	2.12
AF0001_AC401 Exclusive	Covid Exclusive	0.01	-0.95	-0.86	-0.23	5.20
Covid Exclusive	Overlap	0.00	41.85	34.03	19.09	4.59
AF0001_AC401 Exclusive	Overlap	0.00	0.99	-0.07	0.99	-0.17
Overlap	Exclusives	0.04	4.84	22.82	6.42	33.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	85	81	MBL3P;SRY;HLA-DRB4;UNC93B
AF0001_AC401 Exclusive	168	168	
Overlap	1	1