Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	AF0001_AC40	3.77e-10	7.99e-01	1.86e-02	2.19e-03
AF0001_AC40	Viral	7.10e-02	3.93e-01	1.60e-03	6.47e-08



Evaluating how well Viral genes are linked to AF0001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC40	0.58	-1.08	-0.11	0.18	3.53
AF0001_AC40	Viral	0.67	-0.62	-0.84	0.40	6.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	AF0001_AC40	0.01	-2.06	-0.79	-0.17	2.23
AF0001_AC40	Viral	0.01	-1.00	-2.02	-0.14	2.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	124	111	MBL3P;TNFα;SNORA31;UNC93B;HLA;HLA-DRB4;IFNL4;IL12;SRY;Mig;HLA-DRB3;FCER;HLA-Cw
AF0001_AC40	154	154