Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	AF0001_AC40	6.74e-10	3.93e-01	1.17e-02	4.25e-04
AF0001_AC40	Covid	7.21e-02	3.41e-01	7.42e-02	1.04e-07



Evaluating how well Covid genes are linked to AF0001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC40	0.58	-0.97	-0.40	0.12	3.55
AF0001_AC40	Covid	0.67	-0.58	-0.77	0.24	6.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	AF0001_AC40	0.01	-1.76	-1.08	-0.22	1.46
AF0001_AC40	Covid	0.01	-0.85	-1.84	-0.31	4.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	86	82	HLA-DRB4;MBL3P;UNC93B;SRY
AF0001_AC40	154	154