Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Casanova	AF0001_AC40	3.13e-07	5.32e-01	4.21e-01	5.85e-03
AF0001_AC40	Casanova	1.59e-03	1.14e-01	6.78e-01	1.51e-01



Evaluating how well Casanova genes are linked to AF0001_AC40 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC40	0.58	0.26	-0.76	-0.47	3.20
AF0001_AC40	Casanova	0.61	-2.71	-1.68	-0.56	1.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Casanova	AF0001_AC40	0.01	-0.09	-1.64	-0.52	1.09
AF0001_AC40	Casanova	0.00	-1.24	-1.04	-0.62	-0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Casanova	13	12	UNC93B
AF0001_AC40	154	154