Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet-Rare Exclusive	BRCA-Familial_v2	9.81e-03	1.64e-03	1.08e-18	4.53e-16
BRCA-Familial_v2 Exclusive	Wavelet-Rare	1.01e-04	5.60e-04	8.10e-31	3.31e-43
Wavelet-Rare Exclusive	BRCA-Familial_v2 Exclusive	1.79e-03	1.69e-03	1.33e-14	3.15e-11
BRCA-Familial_v2 Exclusive	Wavelet-Rare Exclusive	1.37e-03	4.80e-03	4.14e-28	3.40e-40
Wavelet-Rare Exclusive	Overlap	2.65e-03	1.46e-03	2.08e-05	1.12e-05
BRCA-Familial_v2 Exclusive	Overlap	2.12e-06	1.65e-05	3.30e-07	7.29e-07
Overlap	Exclusives	1.29e-11	6.20e-05	2.53e-50	8.82e-42



Evaluating how well Wavelet-Rare genes are linked to BRCA-Familial_v2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Rare Exclusive	BRCA-Familial_v2	0.97	2.48	4.94	2.32	6.95
BRCA-Familial_v2 Exclusive	Wavelet-Rare	0.80	1.77	3.62	4.23	15.86
Wavelet-Rare Exclusive	BRCA-Familial_v2 Exclusive	0.96	2.55	4.78	2.45	6.12
BRCA-Familial_v2 Exclusive	Wavelet-Rare Exclusive	0.79	1.72	3.45	4.33	13.90
Wavelet-Rare Exclusive	Overlap	0.98	2.61	2.34	1.85	4.05
BRCA-Familial_v2 Exclusive	Overlap	0.99	1.60	4.03	3.00	4.26
Overlap	Exclusives	0.80	3.65	6.18	2.78	16.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Rare Exclusive	BRCA-Familial_v2	0.09	1.37	31.72	23.43	173.20
BRCA-Familial_v2 Exclusive	Wavelet-Rare	0.05	1.51	9.63	13.34	43.51
Wavelet-Rare Exclusive	BRCA-Familial_v2 Exclusive	0.02	1.65	7.94	11.98	32.69
BRCA-Familial_v2 Exclusive	Wavelet-Rare Exclusive	0.04	1.14	5.32	11.32	27.04
Wavelet-Rare Exclusive	Overlap	0.17	1.20	92.22	33.67	404.86
BRCA-Familial_v2 Exclusive	Overlap	0.05	6.67	97.52	49.41	166.13
Overlap	Exclusives	0.05	6.26	16.47	11.71	39.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet-Rare Exclusive	214	212	;CHD2
BRCA-Familial_v2 Exclusive	16	16	
Overlap	7	7