Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet-Rare Exclusive	All-Familial	1.20e-01	5.29e-03	1.08e-23	1.51e-18
All-Familial Exclusive	Wavelet-Rare	3.65e-09	4.42e-04	7.60e-38	1.68e-45
Wavelet-Rare Exclusive	All-Familial Exclusive	6.64e-02	6.48e-03	1.39e-18	1.26e-14
All-Familial Exclusive	Wavelet-Rare Exclusive	2.83e-06	2.26e-02	2.40e-32	5.44e-41
Wavelet-Rare Exclusive	Overlap	3.89e-01	3.09e-01	6.15e-07	1.22e-06
All-Familial Exclusive	Overlap	1.66e-08	7.49e-08	1.52e-11	5.66e-11
Overlap	Exclusives	6.37e-14	1.51e-06	1.42e-46	1.28e-51



Evaluating how well Wavelet-Rare genes are linked to All-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Rare Exclusive	All-Familial	0.87	1.38	5.41	2.95	9.42
All-Familial Exclusive	Wavelet-Rare	0.80	1.64	4.70	4.65	17.22
Wavelet-Rare Exclusive	All-Familial Exclusive	0.85	1.46	4.60	2.75	7.72
All-Familial Exclusive	Wavelet-Rare Exclusive	0.79	1.10	3.77	4.09	15.66
Wavelet-Rare Exclusive	Overlap	0.93	0.64	2.10	2.01	5.61
All-Familial Exclusive	Overlap	0.99	2.43	4.95	2.74	5.77
Overlap	Exclusives	0.80	2.39	6.70	3.58	18.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet-Rare Exclusive	All-Familial	0.04	-0.97	10.59	6.90	52.46
All-Familial Exclusive	Wavelet-Rare	0.05	0.84	10.14	13.87	42.62
Wavelet-Rare Exclusive	All-Familial Exclusive	0.02	-0.06	7.13	8.96	37.58
All-Familial Exclusive	Wavelet-Rare Exclusive	0.04	-0.06	4.09	8.87	29.09
Wavelet-Rare Exclusive	Overlap	0.03	-1.14	8.27	1.68	41.80
All-Familial Exclusive	Overlap	0.10	2.98	152.38	65.29	273.00
Overlap	Exclusives	0.06	3.88	15.32	13.95	52.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet-Rare Exclusive	209	207	;CHD2
All-Familial Exclusive	48	48	
Overlap	12	12