Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
singletons	Nalls eQTL	1.80e-02	1.82e-02	9.54e-04	2.40e-03
Nalls eQTL	singletons	5.40e-07	2.37e-06	3.41e-09	4.46e-10



Evaluating how well singletons genes are linked to Nalls eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singletons	Nalls eQTL	0.72	2.63	2.61	2.32	3.40
Nalls eQTL	singletons	0.92	4.66	5.41	4.38	6.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singletons	Nalls eQTL	0.01	16.65	31.02	21.13	9.54
Nalls eQTL	singletons	0.01	23.35	23.51	21.74	13.61

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
singletons	20	20	
Nalls eQTL	29	27	WNT3 ;LOC100131289