Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
singletons	Nalls eQTL	1.82e-02	2.63e-02	1.42e-03	3.07e-03
Nalls eQTL	singletons	1.79e-07	9.85e-07	1.95e-09	1.41e-09



Evaluating how well singletons genes are linked to Nalls eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singletons	Nalls eQTL	0.72	2.85	2.88	2.57	4.68
Nalls eQTL	singletons	0.92	5.15	5.86	4.78	6.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singletons	Nalls eQTL	0.01	20.02	31.59	25.55	14.26
Nalls eQTL	singletons	0.01	24.95	26.13	22.22	30.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
singletons	20	20	
Nalls eQTL	29	27	WNT3 ;LOC100131289