Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	Jansen	7.49e-02	8.42e-02	1.44e-03	5.19e-01
Jansen Exclusive	Singleton	3.96e-03	1.89e-04	1.29e-02	1.37e-04
Singleton Exclusive	Jansen Exclusive	1.19e-01	2.74e-01	2.15e-03	5.63e-01
Jansen Exclusive	Singleton Exclusive	5.39e-03	6.31e-04	4.79e-02	4.55e-04
Singleton Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Jansen Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	5.25e-15	4.25e-16	2.18e-15	1.62e-17



Evaluating how well Singleton genes are linked to Jansen genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	Jansen	0.53	3.02	1.87	1.32	0.40
Jansen Exclusive	Singleton	0.80	2.05	3.88	2.00	4.85
Singleton Exclusive	Jansen Exclusive	0.51	3.27	0.99	0.79	0.02
Jansen Exclusive	Singleton Exclusive	0.79	2.28	4.30	1.90	4.89
Singleton Exclusive	Overlap	1.00	2.27	1.82	1.99	1.59
Jansen Exclusive	Overlap	1.00	2.01	1.87	2.10	1.86
Overlap	Exclusives	0.89	5.79	11.24	6.39	7.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	Jansen	0.02	45.14	45.82	3.87	3.83
Jansen Exclusive	Singleton	0.01	14.28	42.60	13.22	17.31
Singleton Exclusive	Jansen Exclusive	0.00	10.37	5.20	1.43	0.49
Jansen Exclusive	Singleton Exclusive	0.00	5.39	12.44	3.44	2.32
Singleton Exclusive	Overlap	0.25	1030.31	186.12	735.38	1225.07
Jansen Exclusive	Overlap	0.08	127.86	360.89	246.36	144.16
Overlap	Exclusives	0.09	91.74	183.42	84.14	179.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	19	19	
Jansen Exclusive	26	23	ZN27F543;c11orf21;SSPO
Overlap	1	1