Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	GS1	5.60e-02	5.04e-01	1.03e-01	4.20e-02
GS1	EAML	3.21e-01	6.70e-01	2.17e-06	4.95e-01



Evaluating how well EAML genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS1	0.62	-1.86	-1.08	-1.50	1.99
GS1	EAML	0.46	-0.37	-1.40	-0.71	-1.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS1	0.00	-1.21	-1.08	-1.11	0.13
GS1	EAML	0.00	-0.65	-1.31	-0.67	-1.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	99	99	
GS1	20	20