Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	eQTL	5.02e-01	8.51e-01	2.40e-01	4.25e-01
eQTL	EAML	8.72e-01	7.99e-01	1.37e-02	3.54e-01



Evaluating how well EAML genes are linked to eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	eQTL	0.56	-0.97	-0.71	-1.03	1.37
eQTL	EAML	0.46	-0.37	-0.77	-0.77	-1.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	eQTL	0.00	-0.58	-0.41	-0.66	0.39
eQTL	EAML	0.00	-0.56	-0.81	-0.57	-1.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	99	99	
eQTL	29	27	LOC100131289;WNT3