Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Singleton	6.56e-02	2.73e-01	3.15e-02	2.38e-02
Singleton	EPI	5.34e-01	6.03e-01	1.62e-07	6.15e-01



Evaluating how well EPI genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singleton	0.65	-1.02	-0.48	-0.79	2.10
Singleton	EPI	0.47	-0.02	-0.61	-0.21	-1.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singleton	0.00	-1.11	-1.12	-0.86	0.38
Singleton	EPI	0.01	-0.46	-1.13	-0.79	-1.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	128	127	AC010255.3
Singleton	20	20