Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Singletonn	8.85e-01	8.23e-01	8.26e-01	3.20e-03
Singletonn	EPI	9.35e-01	9.90e-01	4.41e-03	9.15e-01



Evaluating how well EPI genes are linked to Singletonn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singletonn	0.71	0.42	1.01	0.46	3.16
Singletonn	EPI	0.51	0.29	-0.32	0.04	0.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singletonn	0.00	-0.31	0.18	-0.10	1.63
Singletonn	EPI	0.00	0.10	-0.47	-0.31	-0.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	55	55	
Singletonn	20	20