Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Singletons	8.62e-01	8.20e-01	6.95e-01	6.37e-03
Singletons	EPI	9.64e-01	9.91e-01	9.59e-03	9.56e-01



Evaluating how well EPI genes are linked to Singletons genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singletons	0.71	0.25	1.02	0.64	3.46
Singletons	EPI	0.51	0.36	-0.23	0.11	0.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Singletons	0.00	-0.39	0.14	0.01	0.57
Singletons	EPI	0.00	0.23	-0.43	-0.20	-0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	55	55	
Singletons	20	20