Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	eQTL	9.77e-01	6.41e-01	9.03e-01	8.31e-02
eQTL	EPI	8.90e-01	6.25e-01	1.11e-02	2.11e-01



Evaluating how well EPI genes are linked to eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	eQTL	0.63	0.45	1.04	0.55	2.51
eQTL	EPI	0.48	0.15	0.03	-0.13	-0.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	eQTL	0.00	0.22	0.59	0.35	0.52
eQTL	EPI	0.01	0.80	1.15	0.46	0.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	128	127	AC010255.3
eQTL	29	27	WNT3 ;LOC100131289