Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI55	eQTL	7.27e-01	7.20e-01	6.15e-01	1.73e-01
eQTL	EPI55	9.62e-01	4.11e-01	7.70e-02	7.98e-01



Evaluating how well EPI55 genes are linked to eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI55	eQTL	0.61	0.14	0.07	-0.04	1.88
eQTL	EPI55	0.51	-0.11	0.45	0.32	0.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI55	eQTL	0.00	0.36	0.54	0.60	0.32
eQTL	EPI55	0.00	0.26	0.85	0.72	0.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI55	55	55	
eQTL	29	27	LOC100131289;WNT3