Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet 243 Exclusive	eQTL	4.96e-01	6.08e-01	4.57e-05	1.10e-03
eQTL Exclusive	wavelet 243	1.43e-01	9.19e-01	2.70e-04	1.82e-19
wavelet 243 Exclusive	eQTL Exclusive	5.34e-01	6.49e-01	4.10e-05	3.78e-03
eQTL Exclusive	wavelet 243 Exclusive	1.16e-01	8.48e-01	1.15e-03	1.05e-19
wavelet 243 Exclusive	Overlap	5.79e-01	2.84e-01	2.43e-02	4.83e-02
eQTL Exclusive	Overlap	5.27e-02	1.82e-02	2.32e-02	1.65e-02
Overlap	Exclusives	2.60e-02	3.14e-01	6.11e-76	3.07e-37



Evaluating how well wavelet 243 genes are linked to eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet 243 Exclusive	eQTL	0.66	0.73	0.30	0.99	2.84
eQTL Exclusive	wavelet 243	0.67	-0.80	-0.00	-0.10	9.84
wavelet 243 Exclusive	eQTL Exclusive	0.64	1.02	0.30	1.08	2.39
eQTL Exclusive	wavelet 243 Exclusive	0.67	-1.15	-0.10	0.04	8.53
wavelet 243 Exclusive	Overlap	0.92	-2.81	-1.33	0.51	1.90
eQTL Exclusive	Overlap	0.97	2.27	2.02	2.27	2.87
Overlap	Exclusives	0.72	-0.38	0.44	1.23	12.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet 243 Exclusive	eQTL	0.00	-1.11	-1.35	-0.15	0.46
eQTL Exclusive	wavelet 243	0.02	-0.44	0.17	0.67	5.45
wavelet 243 Exclusive	eQTL Exclusive	0.00	-0.59	-1.28	-0.22	1.15
eQTL Exclusive	wavelet 243 Exclusive	0.02	-0.76	-0.37	0.51	6.60
wavelet 243 Exclusive	Overlap	0.00	-1.02	-1.39	-0.36	1.48
eQTL Exclusive	Overlap	0.01	9.20	19.28	31.23	28.60
Overlap	Exclusives	0.03	-0.99	0.06	0.49	11.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet 243 Exclusive	241	239	ARL 11.00;SOS 1
eQTL Exclusive	27	25	LOC100131289;WNT3 
Overlap	2	2