Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet 163 Exclusive	eQTL	5.43e-01	6.88e-01	5.99e-05	1.20e-03
eQTL Exclusive	wavelet 163	3.14e-01	7.91e-01	6.16e-04	3.61e-14
wavelet 163 Exclusive	eQTL Exclusive	4.85e-01	7.48e-01	9.84e-05	2.86e-03
eQTL Exclusive	wavelet 163 Exclusive	2.33e-01	7.88e-01	2.03e-03	1.33e-13
wavelet 163 Exclusive	Overlap	5.66e-01	1.98e-01	2.32e-02	3.53e-02
eQTL Exclusive	Overlap	2.67e-02	1.73e-02	2.00e-02	1.91e-02
Overlap	Exclusives	2.46e-01	5.49e-01	1.04e-59	1.03e-27



Evaluating how well wavelet 163 genes are linked to eQTL genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet 163 Exclusive	eQTL	0.69	2.29	1.22	2.02	3.26
eQTL Exclusive	wavelet 163	0.68	-0.56	0.82	0.23	8.48
wavelet 163 Exclusive	eQTL Exclusive	0.67	2.54	1.16	1.72	2.96
eQTL Exclusive	wavelet 163 Exclusive	0.68	-0.75	0.58	0.11	7.58
wavelet 163 Exclusive	Overlap	0.92	-2.48	-0.70	0.94	1.97
eQTL Exclusive	Overlap	0.97	1.98	1.95	2.26	2.61
Overlap	Exclusives	0.73	0.21	0.75	1.55	10.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet 163 Exclusive	eQTL	0.00	-0.03	-0.99	0.42	0.97
eQTL Exclusive	wavelet 163	0.02	0.25	2.69	1.57	7.76
wavelet 163 Exclusive	eQTL Exclusive	0.00	0.81	-0.45	0.44	1.27
eQTL Exclusive	wavelet 163 Exclusive	0.01	-0.12	1.82	1.00	6.77
wavelet 163 Exclusive	Overlap	0.00	-1.24	-1.31	-0.23	0.56
eQTL Exclusive	Overlap	0.01	16.72	20.63	26.38	4.25
Overlap	Exclusives	0.02	-0.58	0.45	0.92	11.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet 163 Exclusive	161	160	ARL 11.00
eQTL Exclusive	27	25	WNT3 ;LOC100131289
Overlap	2	2