Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet243 Exclusive	GWAS	7.36e-01	7.96e-01	2.21e-06	1.70e-02
GWAS Exclusive	wavelet243	5.17e-01	4.53e-02	1.14e-09	9.41e-26
wavelet243 Exclusive	GWAS Exclusive	7.15e-01	6.56e-01	8.07e-06	5.03e-02
GWAS Exclusive	wavelet243 Exclusive	4.35e-01	3.42e-02	2.33e-10	2.85e-25
wavelet243 Exclusive	Overlap	8.41e-01	4.82e-01	1.18e-01	3.00e-01
GWAS Exclusive	Overlap	8.14e-01	5.22e-01	3.98e-01	1.73e-01
Overlap	Exclusives	1.71e-02	1.43e-01	1.18e-61	6.47e-41



Evaluating how well wavelet243 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet243 Exclusive	GWAS	0.60	-0.02	-0.70	0.23	2.92
GWAS Exclusive	wavelet243	0.71	-0.07	2.10	1.89	10.09
wavelet243 Exclusive	GWAS Exclusive	0.59	0.29	-0.75	0.26	2.67
GWAS Exclusive	wavelet243 Exclusive	0.71	-0.19	1.98	1.73	9.91
wavelet243 Exclusive	Overlap	0.79	-1.15	-0.62	0.59	1.68
GWAS Exclusive	Overlap	0.70	-0.63	-0.16	-0.25	1.43
Overlap	Exclusives	0.72	1.40	1.99	1.66	13.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet243 Exclusive	GWAS	0.01	0.06	-0.96	1.12	3.64
GWAS Exclusive	wavelet243	0.02	-0.64	0.68	2.18	13.92
wavelet243 Exclusive	GWAS Exclusive	0.01	0.66	-0.44	1.11	1.15
GWAS Exclusive	wavelet243 Exclusive	0.02	-0.85	0.34	1.74	10.23
wavelet243 Exclusive	Overlap	0.00	-1.41	-1.40	-0.33	0.38
GWAS Exclusive	Overlap	0.02	18.97	78.42	36.38	38.95
Overlap	Exclusives	0.03	0.34	1.21	0.80	12.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet243 Exclusive	240	238	ARL 11.00;SOS 1
GWAS Exclusive	76	75	CASC16
Overlap	3	3