Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet113 Exclusive	GWAS	6.15e-01	8.19e-01	6.15e-05	1.94e-02
GWAS Exclusive	wavelet113	4.11e-01	8.17e-02	1.48e-05	9.45e-18
wavelet113 Exclusive	GWAS Exclusive	6.20e-01	7.77e-01	3.05e-04	2.11e-02
GWAS Exclusive	wavelet113 Exclusive	3.95e-01	9.71e-02	1.58e-05	5.19e-17
wavelet113 Exclusive	Overlap	6.25e-02	1.23e-01	1.15e-02	2.21e-02
GWAS Exclusive	Overlap	5.40e-01	1.43e-01	1.72e-01	2.80e-02
Overlap	Exclusives	9.30e-03	7.93e-02	1.62e-52	1.52e-23



Evaluating how well wavelet113 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet113 Exclusive	GWAS	0.60	0.10	-0.27	0.75	2.65
GWAS Exclusive	wavelet113	0.75	0.44	2.10	2.03	8.35
wavelet113 Exclusive	GWAS Exclusive	0.59	0.26	-0.16	0.50	2.63
GWAS Exclusive	wavelet113 Exclusive	0.74	0.52	2.09	2.11	8.93
wavelet113 Exclusive	Overlap	0.92	-2.60	-0.15	1.36	2.02
GWAS Exclusive	Overlap	0.93	0.74	1.48	1.22	2.30
Overlap	Exclusives	0.73	3.32	3.17	2.11	11.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet113 Exclusive	GWAS	0.01	-0.43	-1.63	1.37	2.18
GWAS Exclusive	wavelet113	0.01	-0.82	0.01	1.35	3.72
wavelet113 Exclusive	GWAS Exclusive	0.01	-0.06	-1.23	0.75	2.42
GWAS Exclusive	wavelet113 Exclusive	0.01	-0.98	-0.47	1.23	5.52
wavelet113 Exclusive	Overlap	0.00	-1.31	-0.80	0.46	0.57
GWAS Exclusive	Overlap	0.02	19.35	148.92	48.07	103.94
Overlap	Exclusives	0.02	4.13	4.21	2.40	9.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet113 Exclusive	111	110	ARL 11.00
GWAS Exclusive	77	76	CASC16
Overlap	2	2