Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML99 Exclusive	GWAS	6.85e-01	9.80e-01	4.85e-01	7.30e-02
GWAS Exclusive	EAML99	9.73e-01	8.80e-01	5.33e-01	6.89e-01
EAML99 Exclusive	GWAS Exclusive	6.82e-01	8.01e-01	4.66e-01	5.77e-02
GWAS Exclusive	EAML99 Exclusive	9.89e-01	8.12e-01	8.40e-01	6.56e-01
EAML99 Exclusive	Overlap	2.58e-01	3.62e-01	1.84e-01	1.23e-01
GWAS Exclusive	Overlap	3.07e-02	1.91e-01	7.69e-02	2.58e-01
Overlap	Exclusives	3.71e-01	9.49e-02	2.40e-04	6.18e-02



Evaluating how well EAML99 genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML99 Exclusive	GWAS	0.57	-0.18	-0.08	-0.23	1.87
GWAS Exclusive	EAML99	0.48	0.06	-0.44	-0.36	-0.70
EAML99 Exclusive	GWAS Exclusive	0.58	-0.10	0.33	-0.18	2.12
GWAS Exclusive	EAML99 Exclusive	0.47	-0.16	-0.59	-0.63	-1.01
EAML99 Exclusive	Overlap	0.25	-1.05	-0.83	-1.08	-1.29
GWAS Exclusive	Overlap	0.82	3.25	1.72	2.01	1.45
Overlap	Exclusives	0.53	-0.32	0.39	-0.12	1.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML99 Exclusive	GWAS	0.00	-0.37	-0.34	-0.47	0.74
GWAS Exclusive	EAML99	0.01	0.33	0.02	0.01	-0.12
EAML99 Exclusive	GWAS Exclusive	0.00	-0.37	0.06	-0.49	1.04
GWAS Exclusive	EAML99 Exclusive	0.00	-0.34	-0.72	-0.67	-0.79
EAML99 Exclusive	Overlap	0.00	-0.32	-0.16	-0.23	-0.60
GWAS Exclusive	Overlap	0.02	98.68	42.80	24.10	0.31
Overlap	Exclusives	0.01	1.05	1.59	2.18	3.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML99 Exclusive	97	97	
GWAS Exclusive	77	76	CASC16
Overlap	2	2