Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
overlap	singleton	3.49e-01	7.85e-01	5.34e-01	4.29e-03
singleton	overlap	8.25e-01	5.90e-01	9.07e-07	7.02e-01



Evaluating how well overlap genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap	singleton	0.70	-0.19	0.75	0.16	2.96
singleton	overlap	0.51	1.03	0.52	0.80	0.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
overlap	singleton	0.00	-0.69	-0.31	-0.47	1.08
singleton	overlap	0.00	0.10	-0.56	-0.08	-0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
overlap	78	78	
singleton	20	20