Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	GS1	2.33e-01	8.62e-01	1.94e-01	1.60e-03
GS1	EAML	1.58e-01	7.02e-01	9.89e-13	3.72e-01



Evaluating how well EAML genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS1	0.71	-0.43	1.02	-0.24	3.89
GS1	EAML	0.47	0.18	-0.65	-0.35	-1.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	GS1	0.00	-0.92	-0.29	-0.96	0.03
GS1	EAML	0.01	1.75	0.28	0.31	0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	207	205	AL133500.1;PNMA6F
GS1	20	20