Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dpp	clnvr	4.68e-03	1.01e-02	1.22e-08	9.09e-08
clnvr	dpp	1.40e-03	4.58e-03	1.24e-07	2.90e-11



Evaluating how well dpp genes are linked to clnvr genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	clnvr	0.84	4.92	5.56	3.75	5.61
clnvr	dpp	0.71	-0.39	3.96	1.08	7.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	clnvr	0.01	2.88	4.83	8.01	9.28
clnvr	dpp	0.02	3.03	7.36	6.44	13.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dpp	128	127	BRD2
clnvr	21	21