Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epp Exclusive	dgn	9.68e-03	7.71e-02	2.13e-31	1.40e-18
dgn Exclusive	epp	1.31e-02	2.40e-02	1.10e-12	2.26e-15
epp Exclusive	dgn Exclusive	8.63e-03	1.02e-01	8.70e-30	1.69e-16
dgn Exclusive	epp Exclusive	3.55e-03	8.26e-02	8.23e-10	6.21e-15
epp Exclusive	Overlap	2.27e-02	1.90e-01	2.13e-04	2.46e-03
dgn Exclusive	Overlap	2.87e-06	4.74e-05	2.62e-06	7.25e-06
Overlap	Exclusives	1.21e-21	1.42e-28	8.12e-67	2.06e-67



Evaluating how well epp genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	dgn	0.69	1.85	2.30	2.48	10.24
dgn Exclusive	epp	0.76	-2.45	3.53	1.91	10.36
epp Exclusive	dgn Exclusive	0.68	2.07	2.64	2.50	8.63
dgn Exclusive	epp Exclusive	0.75	-3.62	2.61	1.42	8.35
epp Exclusive	Overlap	0.91	2.78	1.59	2.50	3.49
dgn Exclusive	Overlap	0.98	3.30	4.39	3.23	4.41
Overlap	Exclusives	0.81	4.62	15.76	3.70	18.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	dgn	0.02	1.15	0.94	4.02	16.60
dgn Exclusive	epp	0.02	-1.50	8.20	5.94	24.96
epp Exclusive	dgn Exclusive	0.02	1.05	1.08	3.79	9.28
dgn Exclusive	epp Exclusive	0.02	-3.45	2.22	2.23	14.28
epp Exclusive	Overlap	0.00	8.03	-0.54	5.92	4.72
dgn Exclusive	Overlap	0.05	79.47	127.43	151.45	108.23
Overlap	Exclusives	0.07	11.90	39.69	8.90	38.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epp Exclusive	114	113	BRD2
dgn Exclusive	202	200	C10orf105;MCIDAS
Overlap	6	6