Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dpp	gwas1	1.91e-01	4.92e-02	2.60e-03	1.91e-03
gwas1	dpp	2.55e-01	1.19e-01	1.76e-04	1.02e-04



Evaluating how well dpp genes are linked to gwas1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas1	0.66	0.76	1.91	1.36	3.21
gwas1	dpp	0.62	0.75	1.44	1.14	3.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas1	0.00	1.24	0.73	1.36	1.05
gwas1	dpp	0.01	1.43	0.56	0.69	2.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dpp	84	84	
gwas1	25	24	HLA -DRB1