Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dpp	gwas2	1.26e-01	3.00e-02	1.88e-03	2.37e-03
gwas2	dpp	2.91e-01	1.58e-01	2.39e-02	5.66e-04



Evaluating how well dpp genes are linked to gwas2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas2	0.63	0.92	2.60	1.99	3.19
gwas2	dpp	0.62	1.23	1.63	1.45	3.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas2	0.00	0.56	1.48	0.89	2.87
gwas2	dpp	0.01	0.56	0.86	1.87	2.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dpp	84	84	
gwas2	39	38	HLA