Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dpp	clnvr	1.55e-02	2.07e-02	4.74e-04	2.09e-05
clnvr	dpp	6.78e-02	5.37e-02	6.03e-06	6.96e-05



Evaluating how well dpp genes are linked to clnvr genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	clnvr	0.76	2.00	2.71	1.85	4.45
clnvr	dpp	0.65	2.02	2.85	2.07	4.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	clnvr	0.01	2.59	6.55	5.40	3.16
clnvr	dpp	0.01	2.90	4.36	3.36	2.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dpp	84	84	
clnvr	21	21