Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
dpp	gwas1	5.84e-01	4.98e-02	9.45e-04	3.16e-03
gwas1	dpp	5.80e-01	3.65e-01	1.88e-01	6.32e-04



Evaluating how well dpp genes are linked to gwas1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas1	0.69	-0.02	2.43	1.21	3.58
gwas1	dpp	0.74	0.77	1.80	1.48	4.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
dpp	gwas1	0.00	0.01	0.73	0.27	0.28
gwas1	dpp	0.00	1.01	0.30	3.06	0.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
dpp	22	22	
gwas1	25	24	HLA -DRB1