Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epp Exclusive	ctd	4.63e-01	2.53e-01	6.84e-09	5.52e-09
ctd Exclusive	epp	9.47e-02	3.53e-01	1.40e-01	1.98e-03
epp Exclusive	ctd Exclusive	5.30e-01	3.63e-01	5.11e-09	2.76e-09
ctd Exclusive	epp Exclusive	1.08e-01	2.86e-01	9.31e-02	3.11e-03
epp Exclusive	Overlap	2.17e-01	4.35e-01	1.18e-01	1.57e-01
ctd Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.95e-24	1.72e-21	6.57e-51	1.15e-39



Evaluating how well epp genes are linked to ctd genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	ctd	0.72	-0.57	1.36	0.41	7.72
ctd Exclusive	epp	0.74	-1.14	1.56	1.12	3.46
epp Exclusive	ctd Exclusive	0.71	-0.67	1.30	0.30	7.26
ctd Exclusive	epp Exclusive	0.72	-1.02	1.22	1.08	3.14
epp Exclusive	Overlap	0.93	1.03	1.10	1.26	1.37
ctd Exclusive	Overlap	1.00	1.17	1.50	1.68	1.76
Overlap	Exclusives	0.89	4.06	11.66	2.65	14.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	ctd	0.01	-0.25	0.45	0.53	7.00
ctd Exclusive	epp	0.01	1.59	14.55	17.46	16.42
epp Exclusive	ctd Exclusive	0.01	-0.33	0.23	0.14	6.78
ctd Exclusive	epp Exclusive	0.00	-1.30	0.27	1.15	0.52
epp Exclusive	Overlap	0.00	0.22	0.99	0.93	0.85
ctd Exclusive	Overlap	0.12	87.03	236.71	506.46	295.26
Overlap	Exclusives	0.05	10.41	49.46	7.37	73.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epp Exclusive	16	16	
ctd Exclusive	102	88	SNAR-I;ATP7;CTR1B;MIR124A-3;MIR296;MIR766;MIR146A;MIR375;MIR505;MIR708;MIR4467;MIR3622B;MIR100;CTR1C
Overlap	1	1