Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epp Exclusive	dgn	9.26e-01	4.20e-01	2.48e-21	1.40e-14
dgn Exclusive	epp	7.73e-01	2.42e-01	8.05e-02	3.15e-04
epp Exclusive	dgn Exclusive	9.10e-01	4.16e-01	1.13e-21	1.48e-14
dgn Exclusive	epp Exclusive	3.15e-01	2.90e-01	3.34e-01	8.75e-04
epp Exclusive	Overlap	5.40e-01	5.66e-01	8.28e-01	4.17e-01
dgn Exclusive	Overlap	1.15e-02	1.35e-02	1.15e-02	1.49e-02
Overlap	Exclusives	2.28e-51	1.78e-45	9.59e-95	1.46e-62



Evaluating how well epp genes are linked to dgn genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	dgn	0.65	-1.63	1.31	-0.01	6.89
dgn Exclusive	epp	0.79	0.99	2.23	1.87	4.23
epp Exclusive	dgn Exclusive	0.65	-1.61	1.20	0.09	8.01
dgn Exclusive	epp Exclusive	0.76	0.72	1.90	1.31	3.32
epp Exclusive	Overlap	0.72	-0.86	-1.63	-0.74	1.05
dgn Exclusive	Overlap	0.99	1.79	2.91	2.07	2.64
Overlap	Exclusives	0.86	4.81	16.34	3.57	23.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epp Exclusive	dgn	0.02	-0.91	0.88	0.21	5.26
dgn Exclusive	epp	0.02	3.90	26.87	23.70	28.82
epp Exclusive	dgn Exclusive	0.02	-0.88	0.54	0.25	6.69
dgn Exclusive	epp Exclusive	0.00	-1.54	-1.18	0.70	3.54
epp Exclusive	Overlap	0.00	-0.52	-0.99	-0.56	0.21
dgn Exclusive	Overlap	0.13	60.21	299.61	273.93	283.62
Overlap	Exclusives	0.08	15.95	69.69	11.81	71.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epp Exclusive	15	15	
dgn Exclusive	206	204	C10orf105;MCIDAS
Overlap	2	2