Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Avg	GS1	1.22e-01	4.28e-01	7.75e-05	4.26e-04
GS1	AC1Avg	2.68e-02	4.15e-01	1.60e-13	8.26e-13



Evaluating how well AC1Avg genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg	GS1	0.77	0.66	0.54	0.79	4.05
GS1	AC1Avg	0.66	0.28	1.44	0.71	8.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg	GS1	0.00	-0.20	0.47	0.42	5.29
GS1	AC1Avg	0.02	-0.07	3.12	1.41	7.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Avg	218	213	ORF71;MC159L;TFDP2;UGT2A1;UL36
GS1	20	20