Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Avg	GS2	4.00e-02	1.19e-01	4.52e-06	9.84e-04
GS2	AC1Avg	2.84e-02	4.06e-04	3.43e-09	7.68e-13



Evaluating how well AC1Avg genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg	GS2	0.68	2.16	1.24	1.54	3.25
GS2	AC1Avg	0.67	0.53	2.57	0.95	8.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg	GS2	0.00	3.33	0.96	1.78	4.92
GS2	AC1Avg	0.02	1.37	6.06	3.02	11.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Avg	218	213	UL36;TFDP2;ORF71;UGT2A1;MC159L
GS2	29	27	WNT3 ;LOC100131289