Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC2Avg Exclusive	GS2	1.02e-01	8.34e-01	2.16e-02	1.00e-01
GS2 Exclusive	AC2Avg	1.20e-02	4.14e-01	1.23e-02	1.01e-08
AC2Avg Exclusive	GS2 Exclusive	8.80e-02	7.98e-01	6.54e-02	1.66e-01
GS2 Exclusive	AC2Avg Exclusive	2.61e-02	2.56e-01	5.65e-03	1.03e-08
AC2Avg Exclusive	Overlap	9.92e-02	2.52e-01	9.92e-02	1.25e-01
GS2 Exclusive	Overlap	1.18e-01	1.75e-01	1.25e-01	1.57e-01
Overlap	Exclusives	1.69e-02	4.37e-03	1.67e-31	3.12e-21



Evaluating how well AC2Avg genes are linked to GS2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg Exclusive	GS2	0.60	-1.75	-0.98	-0.26	1.74
GS2 Exclusive	AC2Avg	0.63	-1.81	-1.11	-0.56	5.81
AC2Avg Exclusive	GS2 Exclusive	0.59	-1.73	-1.29	-0.76	1.59
GS2 Exclusive	AC2Avg Exclusive	0.63	-1.79	-1.38	-0.65	5.52
AC2Avg Exclusive	Overlap	0.97	0.58	0.95	1.54	1.60
GS2 Exclusive	Overlap	0.93	1.53	1.02	1.59	1.55
Overlap	Exclusives	0.73	0.92	4.67	1.74	10.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC2Avg Exclusive	GS2	0.00	-1.44	-1.12	-0.16	0.27
GS2 Exclusive	AC2Avg	0.01	-1.45	-1.46	-0.35	4.85
AC2Avg Exclusive	GS2 Exclusive	0.00	-1.30	-1.43	-0.80	0.29
GS2 Exclusive	AC2Avg Exclusive	0.01	-1.44	-1.65	-0.39	2.71
AC2Avg Exclusive	Overlap	0.00	0.00	0.40	0.73	0.26
GS2 Exclusive	Overlap	0.00	0.58	0.25	1.78	-0.06
Overlap	Exclusives	0.02	0.77	4.76	1.56	12.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC2Avg Exclusive	172	166	CRMA;SPI-2;UL36;MC159L;TFDP2;ORF71
GS2 Exclusive	28	26	WNT3 ;LOC100131289
Overlap	1	1