Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1Avg Exclusive	Gs3	3.25e-03	3.63e-02	6.80e-10	3.86e-05
Gs3 Exclusive	AC1Avg	8.24e-02	2.82e-03	3.36e-08	3.23e-11
AC1Avg Exclusive	Gs3 Exclusive	7.57e-03	5.59e-02	5.59e-09	1.62e-04
Gs3 Exclusive	AC1Avg Exclusive	7.29e-02	2.83e-03	9.04e-08	2.86e-11
AC1Avg Exclusive	Overlap	3.07e-02	5.04e-02	2.10e-02	8.69e-02
Gs3 Exclusive	Overlap	7.40e-01	8.92e-01	7.66e-01	9.01e-01
Overlap	Exclusives	1.92e-05	4.07e-08	1.46e-04	2.94e-20



Evaluating how well AC1Avg genes are linked to Gs3 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg Exclusive	Gs3	0.62	2.11	1.49	1.53	3.69
Gs3 Exclusive	AC1Avg	0.67	0.90	2.95	1.08	7.76
AC1Avg Exclusive	Gs3 Exclusive	0.61	1.77	1.25	0.85	3.28
Gs3 Exclusive	AC1Avg Exclusive	0.67	0.83	2.39	1.43	7.84
AC1Avg Exclusive	Overlap	0.89	5.22	2.92	2.28	1.87
Gs3 Exclusive	Overlap	0.54	0.80	0.35	0.23	0.31
Overlap	Exclusives	0.70	1.74	7.13	1.75	9.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1Avg Exclusive	Gs3	0.01	4.02	3.49	2.83	2.21
Gs3 Exclusive	AC1Avg	0.03	1.35	9.70	3.54	17.15
AC1Avg Exclusive	Gs3 Exclusive	0.01	3.35	2.48	2.06	1.26
Gs3 Exclusive	AC1Avg Exclusive	0.03	1.00	7.64	4.04	14.21
AC1Avg Exclusive	Overlap	0.00	41.96	9.79	3.47	-0.00
Gs3 Exclusive	Overlap	0.00	-0.09	-0.17	-0.16	-0.17
Overlap	Exclusives	0.03	2.96	14.43	3.60	18.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1Avg Exclusive	216	211	MC159L;UGT2A1;TFDP2;ORF71;UL36
Gs3 Exclusive	77	76	CASC16
Overlap	2	2